DAXX Antikörper

Produktnummer ABIN1843310

Der Maus Monoklonal Anti-DAXX-Antikörper wurde für WB, ELISA, FACS und IF/ICC validiert. Er ist geeignet, DAXX in Proben von Human zu detektieren.

Kurzübersicht für DAXX Antikörper (ABIN1843310)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DAXX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Produktdetails anti-DAXX Antikörper

Aufreinigung: Purified by Protein G affinity chromatography

Immunogen: Purified recombinant fragment of human DAXX expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol and 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Details zu DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Andere Bezeichnung: DAXX

Hintergrund: Daxx is a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF beta R2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF beta R2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.

Molekulargewicht: 81 kDa

Gen-ID: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway